The Topeka House of Prayer will host the event, which begins at 5 p.m. Friday and ends at noon Sunday at the Faith Family Life Centre.
Organizers say the event will focus on praying for Topeka, the state of Kansas and the United States.
The Rev. Mike Shinkle, pastor of Open Way Church and an organizer of the event, said people of all denominations are welcome to the event.
The Topeka Capital-Journal reports that 101 interns from the International House of Prayer in Kansas City, Mo., will lead worship and prayer.